{"text_format":"1","workbook":"xlsx","n_sheets":15,"sheets":["Title Sheet","References","Inputs","Effectiveness","Cost Inputs","Resource Use","Calculations","Comp Model","Tx Costs","Comp Costs","Results","Survival","Cost Chart","SA Chart","SA Chart (2)"],"not_rendered":{"charts":4,"images":2,"macros":1,"external_links":0,"defined_names":2,"comments":6,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Title Sheet","index":0,"n_rows":27,"n_cols":3,"rows_kept":27,"cut":false,"hidden":false,"merged":[[3,2,3,3],[12,2,15,5]]}
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[null,null,"An Economic Evaluation of the Use of Copper in Reducing the Rate of Healthcare Associated Infections in the UK"]
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[null,null,"The purpose of this model is to calculate the number and associated costs of Healthcare Associated Infections in different clinical settings and to evaluate the benefits of a copper intervention on key touch surfaces compared to non-copper items.  It then calculates the Return on Investment (ROI) and indicates other tangible benefits.\nThese assumptions are based on a new build or planned renovation so installation costs (which would be similar) have therefore not been considered.\nThe model should be navigated using the buttons on the left hand side of the screen to go to sections for model Inputs, Calculations and Results and at the top of the page to move to screens within these sections.  It should be noted that the main areas for users are the Inputs and Results sections of the model.\n\nCells within the model are colour coded as follows:"]
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[null,null,"Green background cells"]
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[null,null,"Red text"]
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[null,null,"Comments"]
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[null,null,"v.042013.2.1"]

{"sheet":"References","index":1,"n_rows":186,"n_cols":5,"rows_kept":186,"cut":false,"hidden":false,"merged":[[3,2,3,4],[22,2,22,4],[24,2,24,4],[26,2,26,4]]}
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[null,null,"Model Inputs"]
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[null,null,"Baseline infection rates","Source","Link"]
[null,null,"E. Coli","Quarterly Epidemiological Commentary: Mandatory MRSA, MSSA and E. coli bacteraemia, and C. difficile infection data (up to January–March 2012). Health protection agency. June 2012","http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317135985134"]
[null,null,"Enterobacter aerogenes","Klebsiella, Enterobacter, Serratia, and Citrobacter bacteraemia, England, Wales, and Northern Ireland: 2006-2010. Health protection agency","http://www.hpa.org.uk/hpr/archives/2012/hpr4212_klbsll.pdf"]
[null,null,"MRSA","Epidemiology, clinical and laboratory characteristics of Staphylococcus aureus bacteraemia in a university hospital in UK. I. Das et al. Journal of Hospital Infection (2007) 65, 117-123"]
[null,null,"Pseudomonas aeruginosa","Pseudomonas spp. and Stenotrophomonas maltophilia bacteraemia in England, Wales, and Northern Ireland, 2007 to 2011. Health protection agency","http://www.hpa.org.uk/webc/HPAwebFile/HPAweb_C/1317135098542"]
[null,null,"Staphilococus aureus","Epidemiology, clinical and laboratory characteristics of Staphylococcus aureus bacteraemia in a university hospital in UK. I. Das et al. Journal of Hospital Infection (2007) 65, 117-123"]
[null,null,"Vancomycin-resistant enterococcus faecalis (VRE)","European survey of vancomycin-resistant enterococci in at-risk hospital wards and in vitro susceptibility testing of ramoplanin against these isolates. Goossens et al. Journal of Antimicrobial Chemotherapy (2003) 51, Suppl. S3, iii5–iii12"]
[null,null,"All healthcare associated infections","Prevalence of healthcare-associated infection in Scottish intensive care units. Cairns et al. Journal of Hospital Infection. 76 (2010) 308-310","http://www.ncbi.nlm.nih.gov/pubmed/20970880"]
[null,null,null,"English National Point Prevalence Survey on Healthcare-associated Infections and Antimicrobial Use, 2011. Health Protection Agency","http://www.hpa.org.uk/Publications/InfectiousDiseases/AntimicrobialAndHealthcareAssociatedInfections/1205HCAIEnglishPPSforhcaiandamu2011prelim/"]
[null,null,"Effectiveness"]
[null,null,"Reduced contamination in a ward setting","The Antimicrobial Efficacy of Copper Alloy Furnishing in the Clinical Environment: A Crossover Study. Kapranan et al. Infection Control and Hospital Epidemiology 2012;33(1):3-9","http://www.jstor.org/stable/10.1086/663644"]
[null,null,"Reduced risk of HCAI in an ICU setting","Risk Mitigation of Hospital Acquired Infections Through the Use of Antimicrobial Copper Surfaces. Schmidt et al BMC Proceedings 2011, 5 (Suppl 6):O53 (Oral presentation delivered at 1st WHO International Conference on Prevention and Infection Control, June 29-July 2, 2011, Geneva, Switzerland)","http://www.biomedcentral.com/1753-6561/5/S6/O53"]
[null,null,null,"Cassandra D. Salgado, MD; Kent A. Sepkowitz, MD; Joseph F. John, MD; J. Robert Cantey, MD; Hubert H. Attaway, MS; Katherine D. Freeman, Dr PH; Peter A. Sharpe, MBA; Harold T. Michels, PhD; Michael G. Schmidt, PhD. Copper Surfaces Reduced the Rate of Healthcare-Acquired Infections in the Intensive Care Unit.  Infection Control and Hospital Epidemiology 2013;34","http://www.jstor.org/stable/10.1086/670207"]
[null,null,"Costs"]
[null,null,"Cost of an additional day in hospital due to infection","International Programme for Resource Use in Critical Care (IPOC) — a methodology and initial results of cost and provision in four European countries. Negrini et al. Acta Anaesthesiologica Scandinavica 2006; 50: 72-79","http://www.ncbi.nlm.nih.gov/pubmed/16451154 "]
[null,null,"QALY"]
[null,null,"Surgical site infection","Lee, Bruce Y, Staphylococcus aureus vaccine for orthopedic patients: an economic model and analysis., Vaccine 2010-Mar-11; 28(12):2465-71","http://www.ncbi.nlm.nih.gov/pubmed/20064479"]
[null,null,"Length of stay"]
[null,null,"ICU","Review for the NHS Executive of Adult Critical Care Services: An International Perspective. Department of Health","http://www.wales.nhs.uk/sites3/Documents/530/adult%20critical%20care-%20international%20perspective.pdf"]
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[null,1]

{"sheet":"Inputs","index":2,"n_rows":135,"n_cols":7,"rows_kept":135,"cut":false,"hidden":false,"merged":[[23,3,23,6],[21,3,21,6],[3,2,3,4],[15,3,15,4],[16,3,16,4],[8,2,10,13],[12,3,12,4],[14,3,14,4],[13,3,13,4]]}
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[null,null,"Model Inputs"]
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[null,null,"The purpose of this sheet is to set up the model for the appropriate hospital setting.  The typical number of patients and any predictions for increases or decreases over time should be entered in the cells shaded in green.  Whether or not copper items will be introduced to general wards, ICU or single rooms can be selected in the drop down menu and the name of the pathogen in the model can be entered in the appropriate green shaded cell ."]
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[null,null,"Number of beds in unit",20]
[null,null,"Average length of stay in ICU (days)",5.7]
[null,null,"Average length of stay ward/single room (days)",3]
[null,null,"Calculated number of patients per year (Cohort)",{"$f":"IF(E74=1,ROUNDDOWN(D13*365/D14,-2),ROUNDDOWN(D13*365/D15,-2))","v":1200}]
[null,null,"Yearly change in number of patients",0]
[]
[null,null,"Setting"]
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[null,null,"Infection to be included in the model:","All Healthcare Associated Infections"]
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[null,null,"Currency:"]
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[null,null,"Green background cells"]
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[null,null,"Red text"]
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[null,null,"Comments"]
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[null,null,{"$f":"MID(CELL(\"filename\"),SEARCH(\"[\",CELL(\"filename\"))+1,SEARCH(\"]\",CELL(\"filename\"))-SEARCH(\"[\",CELL(\"filename\"))-1)","v":"YHEC-model-hcai-economic-evaluation.xlsm"}]
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[null,null,"v.042013.2.1"]
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[null,null,"Selected pathogens"]
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[]
[null,null,"E. Coli",null,false,{"$f":"IF(E65=TRUE,1,0)","v":0}]
[null,null,"Enterobacter aerogenes",null,false,{"$f":"IF(E66=TRUE,1,0)","v":0}]
[null,null,"MRSA",null,false,0]
[null,null,"Pseudomonas aeruginosa",null,false,0]
[null,null,"Staphilococus Aureus",null,false,0]
[null,null,"Vancomycin-resistant Enterococcus faecalis (VRE)",null,false,0]
[null,null,"All Hospital Acquired Infections",null,true,1]
[null,null,"selected setting"]
[]
[null,null,"ICU",null,1,{"$f":"VLOOKUP(E74,F78:G80,2)","v":"ICU"}]
[null,null,"Ward"]
[null,null,"Single room"]
[]
[null,null,null,null,null,1,"ICU"]
[null,null,null,null,null,2,"Ward"]
[null,null,null,null,null,3,"Single room"]
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[null,null,"selected setting",null,3]
[]
[null,null,"Copper objects travel out of room"]
[null,null,"Copper bed rails, other objects travel out of room"]
[null,null,"Copper objects never travel out of room"]
[]
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[null,null,"E. Coli"]
[null,null,"Enterobacter aerogenes"]
[null,null,"MRSA"]
[null,null,"Pseudomonas aeruginosa"]
[null,null,"Staphilococus aureus"]
[null,null,"Vancomycin-resistant enterococcus faecalis (VRE)"]
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[null,null,"GBP Pounds (£)",1]
[null,null,"Euro (€)"]
[null,null,"US Dollar ($)"]

{"sheet":"Effectiveness","index":3,"n_rows":185,"n_cols":33,"rows_kept":185,"cut":false,"hidden":false,"merged":[[12,6,12,8],[11,3,11,11],[12,9,12,11],[3,2,3,3],[102,3,102,4],[102,5,103,5],[12,3,12,5],[8,2,9,9],[24,6,24,8],[26,2,26,11]]}
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[null,null,"Model Inputs"]
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[null,null,"The following infection rates are taken from published papers. To change to hospital specific rates, the rate and the time period in months over which the infections occurred should be entered into the appropriate cells and 'user defined data' should be selected in the drop down menu. A new monthly rate will automatically be calculated. "]
[]
[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"E. Coli"]
[null,null,null,"Monthly infection rate",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Enterobacter aerogenes"]
[null,null,null,"ICU",null,null,"Ward",null,null,"Single room",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"MRSA"]
[null,null,null,"Rate","Time period (months)","Monthly rate","Rate","Time period (months)","Monthly rate","Rate","Time period (months)","Monthly rate",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Pseudomonas aeruginosa"]
[null,null,"E. Coli",{"$f":"61/100000","v":6.0999999999999997E-4},10,{"$f":"D15/E15","v":6.0999999999999999E-5},null,null,{"$f":"IFERROR(0,G15/H15)","v":0},null,null,{"$f":"IFERROR(0,J15/K15)","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Staphilococus Aureus"]
[null,null,"Enterobacter aerogenes",{"$f":"0.58/100000","v":5.7999999999999995E-6},12,{"$f":"D16/E16","v":4.8333333333333329E-7},null,null,{"$f":"IFERROR(0,G16/H16)","v":0},null,null,{"$f":"IFERROR(0,J16/K16)","v":0},null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Vancomycin-resistant Enterococcus faecalis (VRE)"]
[null,null,"MRSA",{"$f":"(37/10000)*0.59","v":2.183E-3},14,1.5592857142857143E-4,null,null,0,null,null,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"All Hospital Acquired Infections"]
[null,null,"Pseudomonas aeruginosa",{"$f":"5.5/100000","v":5.5000000000000002E-5},12,4.5833333333333332E-6,null,null,0,null,null,0]
[null,null,"Staphilococus aureus",{"$f":"(37/10000)*0.41","v":1.5169999999999999E-3},14,1.0835714285714286E-4,null,null,0,null,null,0]
[null,null,"Vancomycin-resistant enterococcus faecalis (VRE)",0.104,12,8.6666666666666663E-3,null,null,0,null,null,0]
[null,null,"All healthcare associated infections",{"$f":"IF($C$180=1,D22,IF($C$180=2,D23,D24))","v":0.27100000000000002},{"$f":"IF($C$180=1,E22,IF($C$180=2,E23,E24))","v":12},2.2583333333333334E-2,{"$f":"IF(G24=\"\",\"\",G24)","v":""},{"$f":"IF(H24=\"\",\"\",H24)","v":""},{"$f":"IFERROR(G21/H21,\"\")","v":""},{"$f":"IF(J24=\"\",\"\",J24)","v":""},{"$f":"IF(K24=\"\",\"\",K24)","v":""},{"$f":"IFERROR(J21/K21,\"\")","v":""}]
[null,null,"   Cairns et al. 2010",0.27100000000000002,12,2.2583333333333334E-2]
[null,null,"   Health Protection Agency 2011",0.23400000000000001,12,1.95E-2]
[null,null,"   User defined data",null,null,{"$f":"IFERROR(D24/E24,\"\")","v":""}]
[]
[null,null,"Reduction in infections*",0.2]
[null,null,"*Rates from Salgado (2013) showed a reduction of 58.1% for the copper arm versus non-copper arm.  A conservative assumption of a reduction of 20% has been used as default in the model."]
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[null,null,"Green background cells"]
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[null,null,"Red text"]
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[null,null,"Comments"]
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[null,null,"58-111"]
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["."]
[null,null,"Percentage healthy"]
[null,null," - copper",{"$f":"1-(SUM(E105:E110))","v":1}]
[null,null," - baseline",{"$f":"1-(SUM(D105:D110))","v":1}]
[null,null,"E. Coli",{"$f":"1/F105","v":1}]
[null,null,"Enterobacter aerogenes",{"$f":"1/F106","v":1}]
[null,null,"MRSA",1]
[null,null,"Pseudomonas aeruginosa",1]
[null,null,"Staphilococus Aureus",1]
[null,null,"Vancomycin-resistant Enterococcus faecalis (VRE)",1]
[null,null,"All Hospital Acquired Infections",1]
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[null,1]
[null,2,null,{"$f":"Results!F12","v":94.095940959409916},null,null,null,null,null,{"$f":"Results!D59","v":1}]
[null,3,0,"Cost increasing",null,{"$f":"D26","v":0.2},null,null,0,{"$error":"#N/A"},null,{"$f":"D26","v":0.2}]
[null,4,0.05,376.38376383763438,null,{"$f":"F75","v":0.2},null,null,0.05,4,null,{"$f":"L75","v":0.2}]
[null,5,0.1,188.19188191882245,null,{"$f":"F76","v":0.2},null,null,0.1,2,null,{"$f":"L76","v":0.2}]
[null,6,0.15,125.46125461254725,null,0.2,null,null,0.15,2,null,0.2]
[null,7,0.2,94.095940959409916,null,0.2,null,null,0.2,1,null,0.2]
[null,8,0.25,75.27675276752818,null,0.2,null,null,0.25,1,null,0.2]
[null,9,0.3,62.730627306273391,null,0.2,null,null,0.3,1,null,0.2]
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[null,null,0.6,31.365313653136571,null,0.2,null,null,0.6,1,null,0.2]
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[null,null,0.7,26.88455455983134,null,0.2,null,null,0.7,1,null,0.2]
[null,null,0.75,25.092250922509244,null,0.2,null,null,0.75,1,null,0.2]
[null,null,0.8,23.523985239852419,null,0.2,null,null,0.8,1,null,0.2]
[null,null,0.85,22.140221402214042,null,0.2,null,null,0.85,1,null,0.2]
[null,null,0.9,20.910209102091038,null,0.2,null,null,0.9,1,null,0.2]
[null,null,0.95,19.809671780928355,null,0.2,null,null,0.95,1,null,0.2]
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[null,null,{"$f":"D26","v":0.2},{"$f":"Results!F12","v":94.095940959409916},null,null,null,null,{"$f":"D26","v":0.2},{"$f":"Results!D59","v":1}]
[]
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[]
[]
[null,null,"Rates used"]
[]
[null,null,null,"Infection rate",null,"Length of infection (months)"]
[null,null,null,"Baseline","Copper"]
[null,null,"E. Coli",{"$f":"IF(Inputs!$E$74=1,F15*Inputs!F65,IF(Inputs!$E$74=2,I15*Inputs!F65,IF(Inputs!$E$74=3,L15*Inputs!F65)))","v":0},{"$f":"D105*(1-$D$26)","v":0},1]
[null,null,"Enterobacter aerogenes",{"$f":"IF(Inputs!$E$74=1,F16*Inputs!F66,IF(Inputs!$E$74=2,I16*Inputs!F66,IF(Inputs!$E$74=3,L16*Inputs!F66)))","v":0},{"$f":"D106*(1-$D$26)","v":0},1]
[null,null,"MRSA",{"$f":"IF(Inputs!$E$74=1,F17*Inputs!F67,IF(Inputs!$E$74=2,I17*Inputs!F67,IF(Inputs!$E$74=3,L17*Inputs!F67)))","v":0},0,1]
[null,null,"Pseudomonas aeruginosa",{"$f":"IF(Inputs!$E$74=1,F18*Inputs!F68,IF(Inputs!$E$74=2,I18*Inputs!F68,IF(Inputs!$E$74=3,L18*Inputs!F68)))","v":0},0,1]
[null,null,"Staphilococus aureus",{"$f":"IF(Inputs!$E$74=1,F19*Inputs!F69,IF(Inputs!$E$74=2,I19*Inputs!F69,IF(Inputs!$E$74=3,L19*Inputs!F69)))","v":0},0,1]
[null,null,"Vancomycin-resistant enterococcus faecalis (VRE)",{"$f":"IF(Inputs!$E$74=1,F20*Inputs!F70,IF(Inputs!$E$74=2,I20*Inputs!F70,IF(Inputs!$E$74=3,L20*Inputs!F70)))","v":0},0,1]
[null,null,"Any hospital acquired infections",{"$f":"IF(Inputs!$E$74=1,F21*Inputs!F71,IF(Inputs!$E$74=2,I21*Inputs!F71,IF(Inputs!$E$74=3,L21*Inputs!F71)))","v":2.2583333333333334E-2},1.8066666666666668E-2,1]
["."]
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[null,null,null,null,{"$f":"Inputs!$D$133","v":1}]
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["."]
[null,null,"Cairns 2010"]
[null,null,"HPA 2011"]
[null,null,"User defined data"]
[null,null,1]
[]
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[]
[null,null,1]
["."]

{"sheet":"Cost Inputs","index":4,"n_rows":138,"n_cols":21,"rows_kept":138,"cut":false,"hidden":false,"merged":[[27,2,27,7],[3,2,3,3],[19,3,19,4],[19,6,19,7],[14,5,14,7],[14,2,14,3],[15,2,15,3],[16,2,16,3],[9,2,11,13]]}
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[null,null,"Model Inputs"]
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[null,null,"This sheet is used to calculate the cost of an infection and the copper intervention.  Costs included are the unit cost for one additional day the patient will stay in hospital due to acquiring an infection and further GP and outpatient costs after leaving hospital.  (The number of excess hospital days, GP visits and outpatient visits that a patient may need are entered in the Resource Use sheet.)   The default costs for equipment are for those used in the Salgado study.  Optional copper items can also be added but it should be noted that this only adds to the cost of the copper intervention as the model is unable to take into account any additional benefit given the clinical evidence currently available."]
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[null,null,null,null,"Unit cost",null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Total per event"]
[null,null,"Cost of an additional day in hospital due to infection",null,1000,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"E. Coli",{"$f":"$E$15*'Resource Use'!D15+$E$16*'Resource Use'!E15+$E$17*'Resource Use'!F15","v":5000}]
[null,null,"Visit to general practitioner",null,0,null,null,null,null,null,null,null,null,null,null,null,null,null,null,"Enterobacter aerogenes",{"$f":"$E$15*'Resource Use'!D16+$E$16*'Resource Use'!E16+$E$17*'Resource Use'!F16","v":4000}]
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[null,null,"This sheet is used to enter the resources a patient will use as a result of acquiring an infection.  These are extra days in hospital and subsequent visits to a GP and/or an outpatient visit.  These resources are assumptions and should be changed to reflect local care pathways"]
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[null,null,"Resource use for an event"]
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{"sheet":"Comp Model","index":7,"n_rows":192,"n_cols":16,"rows_kept":192,"cut":false,"hidden":false,"merged":[[3,2,3,3],[10,15,12,20]]}
[]
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[null,null,"Calculations"]
[]
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[]
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[null,null,"Month","Cohort","E. Coli","Enterobacter aerogenes","Methicillin-resistant Staphylococcus aureus (MRSA)","Pseudomonas aeruginosa","Staphilococus aureus","Vancomycin-resistant enterococcus faecalis (VRE)",{"$f":"Inputs!D22","v":"All Healthcare Associated Infections"},"All infections",null,"Cumulative infections",null,"The calculations pages show the number of infections each month and a cumulative figure. These pages are purely for transparency of the model and are for information only."]
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{"sheet":"Tx Costs","index":8,"n_rows":218,"n_cols":35,"rows_kept":218,"cut":false,"hidden":false,"merged":[[3,2,3,3],[10,21,15,23]]}
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[null,null,"Calculations"]
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[null,null,"Month","Bed rails","Overbed tray table","Chair","Call button","Data device","IV pole","Other items","E. Coli","Enterobacter aerogenes","Methicillin-resistant Staphylococcus aureus (MRSA)","Pseudomonas aeruginosa","Staphilococus aureus","Vancomycin-resistant enterococcus faecalis (VRE)",null,{"$f":"Inputs!D22","v":"All Healthcare Associated Infections"},"Total (month)","Total (cumulative)",null,"The calculations pages show the number of infections each month and a cumulative figure. These pages are purely for transparency of the model and are for information only.",null,null,null,null,null,null,null,null,null,null,null,null,"month"]
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[null,null,"Month","Bed rails","Overbed tray table","Chair","Call button","Data device","IV pole","Other items","E. Coli","Enterobacter aerogenes","Methicillin-resistant Staphylococcus aureus (MRSA)","Pseudomonas aeruginosa","Staphilococus aureus","Vancomycin-resistant enterococcus faecalis (VRE)",null,{"$f":"Inputs!D22","v":"All Healthcare Associated Infections"},"Total (month)","Total (cumulative)",null,"The calculations pages show the number of infections each month and a cumulative figure. These pages are purely for transparency of the model and are for information only."]
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{"sheet":"Results","index":10,"n_rows":170,"n_cols":6,"rows_kept":170,"cut":false,"hidden":false,"merged":[[26,2,27,5],[3,2,3,5],[5,2,5,5]]}
[]
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[null,null,"An Economic Evaluation of the Use of Copper in Reducing the Rate of Healthcare Associated Infections in the UK."]
[null,null,"The purpose of this model is to calculate the number and associated costs of Healthcare Associated Infections in different clinical settings and to evaluate the benefits of a copper intervention on key touch surfaces compared to non-copper items.  It then calculates the Return on Investment (ROI) and indicates other tangible benefits."]
[]
[null,null,"5 year results"]
[null,null,null,"Copper","Baseline","Incremental"]
[null,null,"Total cost (excluding cost of infections)*",{"$f":"SUM('Tx Costs'!D12:I72)","v":105000},{"$f":"SUM('Comp Costs'!D12:I72)","v":74400},{"$f":"D10-E10","v":30600}]
[null,null,"Number of infections",{"$f":"Calculations!N72","v":1300.7999999999997},{"$f":"'Comp Model'!N72","v":1625.9999999999986},{"$f":"E11-D11","v":325.19999999999891}]
[null,null,"Cost per infection averted (excluding cost of infections)",null,null,{"$f":"IF(F11<0,\"Less effective\",IF(F11=0,IF(F10<0,\"Cost saving\",IF(F10=0,\"No difference\",\"Cost increasing\")),IF(F10<=0,\"Dominant\",F10/F11)))","v":94.095940959409916}]
[null,null,"Total QALYS gained",null,null,{"$f":"F11*(1-0.642)","v":116.4215999999996}]
[null,null,"Cost per QALY",null,null,{"$f":"F10/F13","v":262.83782390896624}]
[null,null,"Cost of infections*",{"$f":"SUM('Tx Costs'!K12:R72)","v":7804800.0000000009},{"$f":"SUM('Comp Costs'!K12:R72)","v":9756000},{"$f":"D15-E15","v":-1951199.9999999991}]
[null,null,"Total cost of intervention*",{"$f":"D15+D10","v":7909800.0000000009},{"$f":"E15+E10","v":9830400},{"$f":"D16-E16","v":-1920599.9999999991}]
[null,null,"Cost per infection averted",null,null,{"$f":"IF(F11<0,\"Less effective\",IF(F11=0,IF(F16<0,\"Cost saving\",IF(F16=0,\"No difference\",\"Cost increasing\")),IF(F16<=0,\"Dominant\",F16/F11)))","v":"Dominant"}]
[null,null,"*These are direct costs to the hospital (no GP costs or societal costs have been included in the model)"]
[]
[null,null,"Number of bed days saved per year",{"$f":"(F11*'Resource Use'!D21)/5","v":390.2399999999987}]
[null,null,"Cost per bed day day saved per year",{"$f":"F10/D20","v":78.413284132841596}]
[]
[null,null,{"$f":"\"The number of bed days saved per year is \"&TEXT(D20,0)&\", this would allow an increased capacity in the \"&D34&\" by \"&TEXT(D63,0)&\" beds with a typical length of stay of \"&D62&\" days.\"","v":"The number of bed days saved per year is 390, this would allow an increased capacity in the ICU by 68 beds with a typical length of stay of 5.7 days."}]
[]
[null,null,"Return on investment",{"$f":"IFERROR(\"< \"&VLOOKUP(0,'Tx Costs'!AH12:AI191,2,FALSE)&\" months\",\"> 15 years\")","v":"< 1 months"}]
[]
[null,null,{"$f":"IF(Inputs!D133=1,Results!C168,IF(Inputs!D133=3,C170,Results!C169))","v":"The cost of the copper upgrade is £105,000 compared to £74,400 for installation of non-copper items.  There were 1,301 infections in the copper group over the period and 1,626 in the baseline.  This results in a cost per infection averted of £94.10."}]
[]
[]
[null,null,"These results are based on the following scenario:"]
[]
[null,null,"Number of beds per unit",{"$f":"Inputs!D13","v":20}]
[null,null,"Number of patients per year",{"$f":"Inputs!D16","v":1200}]
[null,null,"Setting",{"$f":"Inputs!F74","v":"ICU"}]
[null,null,"Percentage reduction in infections",{"$f":"Effectiveness!D26","v":0.2}]
[null,null,"Type of infection",{"$f":"Inputs!D22","v":"All Healthcare Associated Infections"}]
[]
[null,null,{"$f":"MID(CELL(\"filename\"),SEARCH(\"[\",CELL(\"filename\"))+1,SEARCH(\"]\",CELL(\"filename\"))-SEARCH(\"[\",CELL(\"filename\"))-1)","v":"YHEC-model-hcai-economic-evaluation.xlsm"}]
[]
[null,null,"v.042013.2.1"]
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[null,null,null,{"$f":"VLOOKUP(0,'Tx Costs'!AH12:AI191,2,FALSE)","v":1}]
[]
[]
[null,null,null,{"$f":"IF(Inputs!E74=1,Inputs!D14,Inputs!D15)","v":5.7}]
[null,null,null,{"$f":"IF(Inputs!E74=1,D20/Inputs!D14,D20/Inputs!D15)","v":68.463157894736611}]
[]
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[]
[null,null,{"$f":"\"The cost of the copper upgrade is \"&TEXT(D10,\"£0,0\")&\" compared to \"&TEXT(E10,\"£0,0\")&\" for installation of non-copper items.  There were \"&TEXT(D11,\"0,0\")&\" infections in the copper group over the period and \"&TEXT(E11,\"0,0\")&\" in the baseline.  This results in a cost per infection averted of \"&TEXT(F12,\"£0.00\")&\".\"","v":"The cost of the copper upgrade is £105,000 compared to £74,400 for installation of non-copper items.  There were 1,301 infections in the copper group over the period and 1,626 in the baseline.  This results in a cost per infection averted of £94.10."}]
[null,null,{"$f":"\"The cost of the copper upgrade is \"&TEXT(D10,\"€0,0\")&\" compared to \"&TEXT(E10,\"€0,0\")&\" for installation of non-copper items.  There were \"&TEXT(D11,\"0,0\")&\" infections in the copper group over the period and \"&TEXT(E11,\"0,0\")&\" in the baseline.  This results in a cost per infection averted of \"&TEXT(F12,\"€0.00\")&\".\"","v":"The cost of the copper upgrade is €105,000 compared to €74,400 for installation of non-copper items.  There were 1,301 infections in the copper group over the period and 1,626 in the baseline.  This results in a cost per infection averted of €94.10."}]
[null,null,{"$f":"\"The cost of the copper upgrade is \"&TEXT(D10,\"$0,0\")&\" compared to \"&TEXT(E10,\"$0,0\")&\" for installation of non-copper items.  There were \"&TEXT(D11,\"0,0\")&\" infections in the copper group over the period and \"&TEXT(E11,\"0,0\")&\" in the baseline.  This results in a cost per infection averted of \"&TEXT(F12,\"$0.00\")&\".\"","v":"The cost of the copper upgrade is $105,000 compared to $74,400 for installation of non-copper items.  There were 1,301 infections in the copper group over the period and 1,626 in the baseline.  This results in a cost per infection averted of $94.10."}]

{"sheet":"Survival","index":11,"n_rows":28,"n_cols":4,"rows_kept":28,"cut":false,"hidden":false,"merged":[[3,2,3,3],[21,2,21,4],[27,3,28,7]]}
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[null,null,"Results"]
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[null,null,null,"The red line shows the total number of infections when non-copper items are used, the blue line shows the total number when copper items are used."]

{"sheet":"Cost Chart","index":12,"n_rows":31,"n_cols":4,"rows_kept":31,"cut":false,"hidden":false,"merged":[[3,2,3,3],[21,2,21,4],[27,3,28,7]]}
[]
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[null,null,"Results"]
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[null,null,null,"The red line shows the total cost of infections when non-copper items are used, the blue line shows the total cost when copper items are used."]
[]
[]
[null,null,null,{"$f":"\"The return on investement is \"& IFERROR(\"< \"&VLOOKUP(0,'Tx Costs'!AH12:AI191,2,FALSE)&\" months.\",\"> 15 years.\")","v":"The return on investement is < 1 months."}]

{"sheet":"SA Chart","index":13,"n_rows":42,"n_cols":5,"rows_kept":42,"cut":false,"hidden":false,"merged":[[27,3,29,7],[3,1,3,3]]}
[]
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[null,"   Results"]
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[null,null,"Cost per infection"]
[null,null,"Return on investment"]
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[null,null,null,{"$f":"\"This chart shows the change in the cost per infection averted (the blue line) as the reduction in infections due to copper increases.  The red circle denotes the baseline result entered at input stage (i.e. a reduction in infections of \"&TEXT(E42,0)&\"%).\"","v":"This chart shows the change in the cost per infection averted (the blue line) as the reduction in infections due to copper increases.  The red circle denotes the baseline result entered at input stage (i.e. a reduction in infections of 20%)."}]
[]
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[null,null,null,null,{"$f":"Effectiveness!D26*100","v":20}]

{"sheet":"SA Chart (2)","index":14,"n_rows":28,"n_cols":4,"rows_kept":28,"cut":false,"hidden":false,"merged":[[3,2,3,3],[27,3,29,7]]}
[]
[]
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[null,null,"Results"]
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[]
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[null,null,"Cost per infection"]
[null,null,"Return on investment"]
[]
[]
[]
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[]
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[null,null,null,"This chart shows the change in the cost per infection averted (the blue line) as the reduction in infections due to copper increases.  The red circle denotes the baseline result."]